Zhang Y, et al. - Via this review of cases with colonic neuroendocrine neoplasms (NENs), the characteristics of these patients were studied by researchers, and validation was sought for the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. This study included 167 patients from 12 medical centers across China and 1248 from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States. In both, the Chinese cohort and SEER cohort, significantly distinct clinicopathological characteristics of colonic NENs were identified. In both cohorts, midgut harbored colonic neuroendocrine carcinoma (NEC) and mixed adeno-neuroendocrine carcinoma (MANEC) more frequently than the hindgut. Compared with tumors arising from the hindgut, those from the midgut were larger and at a more advanced stage. For colonic NEC/MANEC, the similar prognostic ability of the AJCC 8th staging system and the ENETS system was suggested.