Feng F, et al. - The features and prognosis of jejunal and ileal gastrointestinal stromal tumors (GISTs) based on the Surveillance, Epidemiology, and End Results (SEER) database were delineated. Jejunal GISTs were more common than ileal GISTs. Except for gender and tumor size, clinicopathological features were comparable between tumors located in the jejunum and ileum. Jejunal GISTs, rather than ileal GISTs, were commonly found in the males. Compared to ileal GISTs, the tumor size of jejunal GISTs was smaller. The disease-specific survival (DSS) of jejunal GISTs and ileal GISTs was comparable. Jejunal and ileal GISTs were also comparable in terms of prognosis.