Tseng HC, et al. - Experts assessed the clinicopathological features and treatment outcomes of cutaneous protothecosis. Due to an increased prevalence of immunocompromised individuals, despite its rarity, cutaneous protothecosis has become more significant. Individuals were predisposed to high-risk infections by steroid overuse or iatrogenic adrenal insufficiency. A chronic and incurable state was led by neglecting the disease. In chronic eczematous and ulcerative plaques on the limbs refractory to conventional antibacterial and antiviral treatments, especially in patients with adrenal insufficiency, authors could suspect protothecosis. Skin biopsies ought to be used to confirm the clinical suspicion, and confirmed cases could be successfully treated with itraconazole.