Budzik MP, et al. - Via analyzing 13 metaplastic breast cancer (MpBC) selected from the group of 1122 invasive breast cancers, they examined histopathology of this type of breast cancer and analyzed estrogen (ER), progesterone (PR) and HER2 receptors expression in these patients. Further, they compared it to other types of invasive breast cancer. They identified that at primary diagnosis, MpBCs are usually larger and mostly present with other poor prognostic indicators and exhibit lack of steroid hormone receptors expression as well as HER2. Findings suggest a correlation of hormone receptor status and HER2 expression with histological grade of malignancy (G1-G3), tumor size (T1a-T4) and regional lymph node involvement (pN0-pN4) and these features are noted to be directly related to MpBC malignancy.