Chung T, Rhee H, Nahm JH, et al. - Given that intrahepatic cholangiocarcinoma (iCCA) is subclassified into mass-forming (MF), periductal-infiltrative (PI), and mixed types grossly, but, their clinicopathological significance remains controversial, researchers sought to analyze clinicopathological features of iCCA gross types based on histopathological type (small-duct, large-duct, indeterminate) or cholangiolocellular differentiation trait (CDT) in 108 iCCAs. Findings revealed that there were 87 MF, 8 PI, and 13 mixed-gross type. Compared with other gross types, MF-type iCCA is more heterogeneous. A good result may be associated with high inflammation marker/low proliferation marker expression in MF-type with CDT or small-duct-type.