Li M, et al. - In this study, investigators examined the data to delineate the correlation of ex-vivo histologic peculiarities with findings recorded in vivo using optical coherence tomography (OCT), near-infrared reflectance imaging, and fundus autofluorescence. A small parafoveal multilobular area of geographic atrophy (GA), subfoveal soft drusen, refractile drusen, hyperreflective lines adjacent to the Bruch membrane, subretinal drusenoid deposit (reticular pseudodrusen), and absence of hyperautofluorescent foci at the GA margin were observed. They reported subretinal drusenoid deposit thick, continuous, extracellular, extensive outside the fovea, and correlated with characteristic retinal pigment epithelium dysmorphia and photoreceptor degeneration. They suggested the requirement of high-quality OCT scans to reveal all tissue features related to age-related macular degeneration progression to GA, particularly the external limiting membrane descent.