Travaglino A, et al. - Via searching electronic databases from January 2011 to January 2019, researchers conducted a systematic review and meta-analysis to evaluate clinical or pathological factors correlated with BRAF-V600E mutation in serrated adenomas. It included 40 studies evaluating 3511 serrated adenomas. Findings suggested an association of BRAF-V600E mutation with proximal localization and CIMP-H status in both sessile serrated (SSA) and traditional serrated adenoma (TSA), with size <10mm only in TSA, and with expression of MUC5A5 and MUC6 and endoscopic pit pattern II-O at least in SSA. BRAF-V600E mutation in serrated adenomas does not appear to be related to age and sex, dysplasia and cancer prevalence, and dysplastic component morphology.