Lee B, et al. - This study was undertaken to determine whether estimates of combined perfusion and vascular permeability metrics derived from DSC-MR imaging can improve the diagnostic performance in differentiating hypervascular primary central nervous system lymphoma from glioblastoma. Results of this study suggested that the estimation of vascular permeability with DSC-MR imaging further identifies the hypervascular primary central nervous system lymphoma and improves diagnostic performance in glioblastoma differentiation. According to the findings obtained, the extraction fraction exhibited the highest diagnostic performance for distinguishing hypervascular primary central nervous system lymphoma from glioblastoma, with a significantly higher performance than both cerebral blood volume (CBV).