Jiang T, et al. - Researchers assessed the predictive and prognostic value of blood neutrophil-to-lymphocyte ratio (NLR) in patients with non-small-cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors by performing a comprehensive online search for published data including hazard ratios (HRs) and 95% confidence interval (CI). They used Stata/MP 14.1 to compute pooled estimates of treatment outcomes. This investigation included 1,700 patients from 16 studies. Findings revealed the association of elevated blood NLR with shorter progression-free survival and overall survival in these patients. Across most subgroups including publication year, study design, research region, PD-L1 expression detection, sample size, NLR cutoff, median follow-up time and study quality score, blood NLR consistently had predictive and prognostic significance. Findings were suggestive of the potential predictive and prognostic value of elevated blood NLR in this clinical scenario.