de Pablo GS, et al. - Researchers investigated the clinical validity of DSM-5 attenuated psychosis syndrome (DSM-5–APS), focusing on recent advances in diagnosis, prognosis, and treatment. They conducted a systematic review including 56 articles and meta-analysis including 23 cohort studies. They tested the clinical validity of DSM-5–APS against evidence-based antecedent, concurrent, and prognostic validators. Association of DSM-5–APS criteria with frequent depressive comorbid disorders, distress, suicidality, and functional impairment was reported. DSM-5–APS has received substantial concurrent and prognostic validation; psychometric research in the field of the clinical high-risk state for psychosis provided most of the validation. However, the available works lack investigation regarding precipitating and predisposing epidemiological factors, neurobiological research, and treatments.