Al-khalidi B, et al. - Objectives of this study were to evaluate the clinical utility of measuring serum 25-hydroxyvitamin-D [25(OH)D] along with traditional risk factors in the diagnosis of insulin resistance (IR) and to determine the optimal 25(OH)D level associated with normal glucose and insulin homeostasis. Among asymptomatic adults, the addition of serum 25(OH)D to traditional risk factors gave a small incremental improvement in detection of IR. The optimal 25(OH)D threshold was estimated to be at least 60 nmol/L. However, the thresholds could differ by ethnic-background. To validate these results in other populations, additional research was required.