Ito Y, et al. - Experts assessed if any of six parameters: prostate volume, total tumor volume (TV), high-grade TV, ratio of high-grade TV to TV, ratio of TV to prostate volume and/or ratio of high-grade TV to prostate volume enhanced the prediction of biochemical recurrence (BCR) following radical prostatectomy (RP). Findings suggested a significant association of the tumor volume-related parameters with BCR. However, these parameters do not add important discrimination to standard clinicopathologic variables for BCR prediction nor provide benefit across a range of clinically-relevant decision thresholds. In routine pathologic evaluation and reporting, volume-related measurement is not warranted.