Michailidou D, et al. - This study was conducted to compare the presence of head, neck, and upper extremity symptoms in individuals with Takayasu’s (TAK) and giant cell arteritis (GCA) and their correlation with vascular inflammation assessed by ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) or arterial damage assessed by magnetic resonance angiography (MRA). Fifty-six individuals with TAK and fifty-four with GCA were included from 270 visits. Carotidynia was recorded only in individuals with TAK (21%) and was correlated with vascular inflammation but not damage in the corresponding carotid artery. Posterior headache was found in TAK (16%) and GCA (20%) but was only correlated with corresponding vertebral artery inflammation and damage in GCA. It was noted that the distribution of symptoms and relationships with imaging abnormalities differs in individuals with TAK and GCA. These data may support clinicians predict correlated FDG-PET and MRA findings based on a specific clinical symptom.