Raouna A, et al. - The literature on the psychiatric risk of offspring of parents with bipolar disorder (OPBD) was systematically reviewed using a developmental psychopathology framework. Researchers here aimed to establish the utility of clinical stage modelling as a framework for identifying precursor disorders to later onset of bipolar disorder (BD) in OPBD. in this work, a developmental psychopathology trajectory of precursor risks to BD in OPBD was supported. For developing early and individualized intervention strategies, clinical stage modelling was supported as a conceptual framework for understanding developmental risk in OPBD and as a tool.