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Clinical spectrum of non-syndromic microphthalmos, anophthalmos and coloboma in the paediatric population: A multicentric study from North India

British Journal of Ophthalmology Aug 26, 2020

Tibrewal S, Subhedar K, Sen P, et al. - Researchers performed this retrospective study to outline the clinical characteristics, visual acuity, and causes of ocular morbidity in children (0–18 years) with microphthalmos, anophthalmos, and coloboma (MAC) from North India. The sample consisted of children with complete clinical data and without syndromic/systemic involvement. In total, 532 children with MAC were examined. Five hundred fifteen children (845 eyes) were involved: 54.4% males and 45.6% females. The MAC group of disorders is responsible for significant ocular morbidity. The presence of microcornea or microphthalmos with coloboma is predictive of a worse best-corrected visual acuity. The difference of the MAC phenotype with the district of origin of the patient raises questions of aetiology and is subject to further investigations.

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