Zuo Y, Ye L, Liu M, et al. - This study was undertaken to investigate the distribution of radiological characteristics stratified by different myositis-specific autoantibodies, distinguish prognostic value of high-resolution CT (HRCT) patterns in dermatomyositis (DM)-associated interstitial lung disease (DM-ILD), and explore the possible mechanism associated with macrophage activation. A total of 165 individuals with PM/DM-ILD were included in this study. This study examined the distribution of HRCT radiological types with different myositis-specific autoantibodies and the association between radiological features and ILD course and prognosis. They further analyzed the potential role of macrophage activation in rapidly progressive ILD (RP-ILD) with DM. The results showed that HRCT patterns are different among variable myositis-specific autoantibodies positive individuals with ILD and lower zone consolidation in HRCT correlated with RP-ILD in DM. In DM, activated macrophages may contribute to the pathogenesis of RP-ILD.