Bischoff MS, et al. - In order to determine the significance of perioperative changes in ankle-brachial index (ABI) with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia (CLI) following revascularization, researchers performed a subanalysis of the multicentric Registry of First-line Treatment in Patients with CLI (CRITISCH). They analyzed 563 of 1200 CRITISCH patients (mean age 74 ± 10.7 years) after exclusion of diabetic patients, conservative cases, and primary major amputation. In non-diabetic patients with CLI, they recommend associating failure of perioperative ABI improvement with a higher probability for amputation and valuing it as a prognostic factor. Close follow-up monitoring is suggested for patients with no/marginal improvement in ABI after revascularization. Early reintervention may benefit these patients.