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Clinical significance of molecular micrometastasis in the sentinel lymph node of early-stage non–small cell lung cancer patients

American Journal of Clinical Oncology Oct 29, 2018

Lafuente-Sanchis A, et al. - In patients with early-stage lung cancer, researchers assessed the prognostic ability of molecular micrometastasis in the sentinel lymph node. For this analysis, they marked the sentinel node quickly after performing thoracotomy by peritumorally injecting 0.25 mCi of nanocoloid of albumin (Nanocol1) labeled with Tc-99m in 0.3 mL. They evaluated the relationship between the presence of micrometastasis, clinicopathologic characteristics, and patients’ outcome. Study participants were 89 stage I-II non–small cell lung cancer patients. In cases staged as stage I/II by hematoxylin-eosin or an immunohistochemical analysis, the molecular analysis of the sentinel node in patients with early-stage lung cancer exhibits node affectation, however, this nodal affectation did not seem to be linked with the patients' result. No significant association was found between the presence of molecular micrometastasis in the sentinel node and patients’ progression, according to survival analysis.

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