Liao G, Chen D, Li J, et al. - Given the value of microRNAs (miRs) as promising biomarkers for early-onset preeclampsia (EOPE), researchers herein examined the role of miR-320a in EOPE. Serum of EOPE patients and normal pregnant women were assessed for expressions of miR-320a and insulin-like growth factor-1 receptor (IGF-1R). EOPE patients showed upregulation of miR-320a, and downregulation of IGF-1R with their differential expressions more obvious in severe EOPE than mild EOPE. Herein researchers identified that miR-320a possesses powerful clinical diagnostic efficacy for EOPE, which may be achieved by directly targeting IGF-1R. In this study, great reference values for EOPE were provided for early diagnosis and novel targets are revealed for EOPE treatment.