Yu J, Yang X, Wu H, et al. - Researchers sought to determine the clinical significance of color ultrasound, magnetic resonance imaging (MRI), miR-21, and CA199 in pancreatic cancer (PC) diagnosis. Participants were 160 patients with PC (PC group) who were admitted to hospital from April 2018 to February 2021, and another 100 patients with benign pancreatic disease during the same period (pancreatic benign disease group), as well as 100 healthy individuals who had physical examination during the same period (control group). A higher detection rate for PC was demonstrated by both color ultrasound and MRI, and significantly higher sensitivity and accuracy were evident in comparison to those of CA199 and miR-21. Findings demonstrated a high application value of the combined detection of color ultrasound, MRI, miR-21, and CA199 in the early diagnosis of PC, which not only can bring about an effective improvement in the sensitivity and accuracy of clinical diagnosis and decrease the chance of missed diagnosis and misdiagnosis but also can afford a reference for the rational clinical treatment plan and prognosis.