Sorosina M, et al. - Researchers undertook an exploration of the consequence of Nabiximol administration on the blood transcriptome profile of multiple sclerosis (MS) patients. They also sought to interpret it in the context of pathways and networks. After 4 weeks of treatment, a downregulation of several immune-related pathways was reported which was more pronounced when restricting analyses to responders. The hub molecules functionally related to the immune system determined were NFKB1, FYN, MAP14 and TP53. Therefore, findings supported the immunomodulatory activity of cannabinoids in MS patients.