Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial
Catheterization and Cardiovascular Interventions Aug 19, 2019
Kogame N, Chichareon P, De Wilder K, et al. - Researchers investigated how all-cause death or new Q-wave myocardial infarction (MI) at 2 years after percutaneous coronary intervention (PCI) for bifurcation lesions was influenced by the receipt of 1-month dual antiplatelet therapy (DAPT) with ticagrelor and aspirin followed by 23-month ticagrelor monotherapy (experimental treatment) vs receiving standard 12-month DAPT followed by 12-month aspirin monotherapy (reference treatment) after the procedure in the GLOBAL LEADERS, which was a randomized, superiority, all-comers trial. As in the overall trial, all-cause death or new Q-wave MI were not explicitly beneficially influenced by the use of 1-month of DAPT followed by ticagrelor monotherapy for 23 months after PCI for bifurcation lesions.
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