Neyaz A, et al. - Utilizing SP263 clone in tissue microarray, 174 cases of gallbladder carcinoma (GBC) were assessed to study the clinical relevance of program death ligand (PD-L1) expression. It was observed that tumor size, growth pattern, presence of necrosis and lympho-vascular emboli demonstrated no significant relationship with PD-L1 in tumor or tumor infiltrating lymphocytes. It was concluded that PD-L1 did not seem to be a prognostic marker or have an influence on survival in GBC. Data revealed that PD-L1 expression occurs in one of four gallbladder cancers, supporting improving the dismal overall survival with a future probability of immune-modulation therapy.