Ali BA, Salman M, Ghanem KM, et al. - Given a dramatic improvement in outcomes in pediatric osteosarcoma over the past few decades, with overall survival rates of 70% and 30% for patients with localized and metastatic disease, respectively, researchers retrospectively reviewed 38 patients treated at a single institution in Lebanon between 2001 and 2012, for clinical characteristics and outcomes. After an average follow-up of 61 months (range, 8 to 142 months), patients with localized disease had 5-year overall and event-free survival rates of nearly 81% and 68%, respectively, whereas, for those with metastatic disease, they were nearly 42%. These findings suggest that in a multidisciplinary cancer center in Lebanon, treatment of pediatric osteosarcoma resulted in survival similar to that in developed countries. They observed a worse outcome in correlation with delay in local control. Poor degree of necrosis at the time of local control was the only statistically significant inferior outcome predictor for these cases.