Carreau AM, et al. - Among 108 overweight and obese adolescents with polycystic ovary syndrome [PCOS] (BMI >90th percentile, age 12-19 years), researchers sought to create a simple clinical score to screen for non-alcoholic fatty liver disease (NAFLD) risk. Study participants were enrolled from 2012-2018. To quantify hepatic fat fraction (HFF), magnetic resonance imaging was used. Investigators found that 52% of the development cohort had NAFLD. Data reported that the PCOS-HS index, which included BMI percentile, waist circumference, ALT and SHBG had an AUCROC of 0.81, sensitivity 82%, specificity 69%, negative predictive value (NPV) 78% and positive predictive value 74%, using a threshold of 0.43 to anticipate HS. It was noted that a threshold of 0.15 ruled out NAFLD with a NPV 90%. The model displayed accuracy of 81%, sensitivity 91% and specificity 70% in the validation cohort. In girls with PCOS who would need further evaluation and treatment, a clinical index was developed to identify NAFLD.