Clinical, pathological, and therapeutic features of newly diagnosed prostate cancer predominantly detected by opportunistic PSA screening: A survey of Shiga Prefecture, Japan
The Prostate Sep 01, 2021
Okinaka Y, Kageyama S, Nishizawa K, et al. - This study’s findings demonstrate that organized prostate-specific antigen (PSA) screening contributes to increasing the number of patients diagnosed with early-stage cancer who can be treated curatively.
Researchers examined 984 newly diagnosed prostate cancer patients in the 2 years 2012 and 2017.
Among these patients, 954 (97%) were opportunistically tested (i.e., not as part of an organized screening system), with the remaining 29 (3%) measured as part of an organized screening program.
A higher initial PSA value was observed in patients with the former group than in the organized screening group (median: 11.49 vs. 5.67 ng/ml). As per the findings, they also had worse clinical features, including higher Gleason score and TNM stage.
In the organized screening group, more patients were treated curatively than in the nonorganized screening group in terms of the primary treatment.
They found similar results in a subanalysis of the patients of age 50–69 years.
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