Burr AR, Harari PM, Haasl AM, et al. - Researchers conducted a retrospective review to assess disease control, toxicities, and dose to dysphagia/aspiration risk structures (DARS) utilizing a direct gross tumor volume (GTV_70Gy) to planning target volume expansion (dPTV_70Gy) for individuals with squamous cell carcinoma of the larynx (LSCC). Seventy-three LSCC patients treated between 2003 and 2018 were identified. Data reported that overall 5-year survival was 57.8% and the distant metastatic-only failure was 2.7%. Five-year local and regional control, respectively, was 79.8% and 88.2%. It was noted that 80% of failures were 95% contained within the dPTV_70Gy. The mean dose and the volume of DARS receiving 70 Gy for dPTV_70Gy was significantly lower compared with a consensus-defined PTV_70Gy. A judicious reduction in the high-dose target volumes can preserve high tumor control rates whereas decreasing the dose to normal surrounding structures, underlining the potential benefit of this approach in enabling the intensification of local therapy to improve locoregional control.