Singh M, et al. - In this single-centre retrospective hospital-based study, which included 40 consecutive adults, researchers described the presentation and prognosis of adrenal histoplasmosis (AH) and cortisol status before and after antifungal therapy. At present, 73% of patients had primary adrenal insufficiency (PAI) and one-third had an adrenal crisis. After one year of antifungal therapy, no patient with PAI became eucortisolemic in re-testing. Investigators discovered that all patients with AH tested negative for HIV antibody. Although after antifungal therapy patients achieved a high rate of clinical remission, the overall mortality rate was significant. Despite treatment, cortisol insufficiency did not normalize.