Al-Jumayli M, et al. - Fifty-four patients who had undergone endoscopic resection or pancreaticoduodenectomy (PD) for Ampullary cancer at KU Cancer Center were retrospectively analyzed for factors associated with overall survival (OS) and for findings that may aid in selecting the modality and regimen of adjuvant therapy [adjuvant chemotherapy (CT) or chemoradiation therapy (CRT)] for resected Ampullary carcinoma. Efforts in rare malignancies such as Ampullary cancer remain very challenging with a clear lack of an evidence-based standard of care treatment paradigm. Researchers observed poor OS in correlation to high-risk features like peripancreatic extension (16%) and perineural invasion (26%). As per finding, patients with high-risk disease may display improvement in survival on receiving adjuvant therapies such as CT or CRT. However, no standardized regimen exists for the treatment of Ampullary cancer.