Hessels AC, et al. - Authors gauged if 5 potential functional haplotypes of the glucocorticoid receptor (GR) gene and a single-nucleotide polymorphism of 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) are related to clinical outcome in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. They compared the relapse-free survival, mortality, renal survival, metabolic adverse events and infections between carriers and non-carriers of GR haplotypes and the HSD11B1 genotype. Findings suggested a correlation of haplotypes 1 and 4 of GR and a polymorphism of the HSD11B1 gene with clinically relevant inflammatory and metabolic outcomes in ANCA-associated vasculitis. They did not note any difference in the occurrence of infections between GR haplotypes and HSD11B1 genotypes.