Zhang N, et al. - Researchers aimed to determine the risk factors of cutaneous allodynia in migraine by comparing clinical characteristics of migraine with and without allodynia. Based on the change in pain threshold after therapy, they assessed the effects of prophylactic therapy on allodynia in patients with migraine. They analyzed 71 patients with migraine admitted to the Department of Neurology of Shandong Provincial Hospital and identified allodynia especially in females who experienced frequent migraine attacks for a prolonged period. Major predictors of allodynia comprised gender, duration of illness, and number of migraine attacks per month. Effective improvement in pain threshold and central sensitization of patients with migraine, and effective relief in allodynia could be achieved by administering topiramate and flunarizine orally for a short duration.