Mito R, Matsubara E, Komohara Y, et al. - In order to find out the clinical effect of tumor-associated calcium signal transducer 2 (TROP2) in non-small lung cancers and its correlation with abnormal p53 nuclear accumulation, researchers investigated TROP2 expression by immunohistochemistry in lung adenocarcinoma (ADC) and squamous cell carcinoma samples, and its association with clinicopathological factors, including survival rate and p53 mutation, was statistically examined. The increased TROP2 expression was found to be significantly correlated with a poor clinical course in individuals with ADC, but not in patients with squamous cell carcinoma. A significant association was found between TROP2 expression and p53 mutation in ADC, and that TROP2 expression was a prognostic factor in ADC cases with a high histological grade as well as those without the EGFR mutation. Signals mediated by mutated p53 might influence TROP2 expression in ADC.