Lin TC, Hung YP, Lee CC, et al. - The risk factors as well as the clinical significance of third-generation cephalosporin nonsusceptibility (3GC-NS) were examined among the cases of monomicrobial Enterobacteriaceae bacteremia (mEB) at regional or district hospitals. Researchers conducted this study at three hospitals in southern Taiwan including only the first episode of mEB from each adult (aged ≥ 20 years). Overall, they included 499 episodes of adults with mEB, and their mean age was 74.5 years. Per findings, 3GC-NS signifies a significant prognostic impact for adults with Enterobacteriaceae bacteremia. Patients infected by 3GC-NS isolates had a higher mortality rate than those by 3GC-susceptible isolates. The only independent prognostic determinant was 3GC-NS in the multivariate analysis. Of note, there was a positive correlation of the following factors with 3GC-NS: male gender, nosocomial-acquired bacteremia, and usage of nasogastric tube. However, P. mirabilis bacteremia and age linked negatively with 3GC-NS. They emphasize incorporating efforts to rapid identification of such antimicrobial resistance profiles into antimicrobial stewardship programs to achieve favorable outcomes.