Sedaghat-Hamedani F, et al. - This research entailed the clinical and genetic characterization of left ventricular non-compaction cardiomyopathy (LVNC) patients. It also gauged the prevalence of variants in known and novel LVNC disease genes. There existed a possibility of the clinical course of symptomatic LVNC being severe. The detected pathogenic variants and distribution of disease genes—a titin-related pathomechanism was disclosed in every fourth patient. This ought to be taken into account in the genetic counselling of patients. A correlation was brought to light between the pathogenic variants in the nuclear proteins Lamin A/C and RBM20 with worse outcome.