Fang X, Wang Y, Yin J, et al. - In this retrospective case series, researchers summarized the clinical characteristics and survival of Chinese patients with trilateral retinoblastoma (TRb), which may help guide early diagnosis and more effective treatments. In order to identify clinical characteristics and outcomes, clinical records of patients with TRb have been reviewed. Among 3,789 patients with retinoblastoma (0.4%), 14 patients with TRb have been identified. A rare intracranial midline neuroblastic disease is trilateral retinoblastoma. Early detection, which has been associated with enhanced results, maybe guided by increased awareness of this disease.