Soovares P, Pasanen A, Similä-Maarala J, et al. - Researchers analyzed the role of clinicopathological factors and 12 immunohistochemical biomarkers (PR, ER, β-catenin, vimentin, ARID1A, HNF1-β, p53, p16, MIB-1, E-cadherin, c-erb-B2 and L1CAM) in prognostic classification of endometrioid ovarian carcinoma (EnOC).

• Findings suggest independent clinical prognostic value of disease stage and grade in endometrioid ovarian carcinoma.

• Distinct survival and gradual change of markers between grades support the 3-tier grading system.

• PR, ER, nuclear β-catenin and vimentin positivity were identified as markers of favorable outcome.

• Aggressive disease was observed in correlation with abnormal expression of p53, overexpression of p16 and L1CAM positivity.