Iino Y, et al. - As eosinophilic otitis media (EOM) shows accumulation of eiosinophils in the middle ear effusion and most EOM patients have high numbers of peripheral blood eosinophils, researchers investigated the efficacy of anti-IL-5 therapy using mepolizumab (reported to be effective for patients with severe and refractory eosinophilic bronchial asthma) in the treatment of EOM. Findings suggest the efficacy of anti-IL-5 therapy using mepolizumab at inhibiting eosinophilic recruitment to the middle ear in these patients. However, patients with the granulation type of EOM showed minimal effect with this therapy. This suggest the viability of this therapy for refractory EOM without severe mucosal change.