Giugliano RP, et al. —This secondary analysis of the FOURIER trial examined the correlation between LDL level achieved at 4 weeks and incidence of cardiovascular events over a median follow-up period of 2.2 years. A monotonic relationship was shown between major cardiovascular outcomes and LDL levels achieved, down to concentrations of less than 0·2 mmol/L. There was no significant relationship between safety concerns and LDL cholesterol levels, even at very low concentrations. These results support lowering LDL in patients with cardiovascular disease below levels that are currently recommended.