Matharu GS, et al. - This study was intended to evaluate the effectiveness and safety of aspirin for venous thromboembolism (VTE) prophylaxis after a total hip replacement (THR) and total knee replacement (TKR). Researchers conducted a systematic review and meta-analysis of randomized clinical trials (RCTs), with no language restrictions, from inception to September 19, 2019, utilizing MEDLINE, Embase, Web of Science, Cochrane Library, and bibliographic searches. A total of 437 articles were distinguished including 6,060 individuals (3,466 [57.2%] women; mean age, 63.0 years). After THR and TKR, aspirin did not differ statistically significantly from other anticoagulants used for VTE prophylaxis in terms of clinical effectiveness and safety profile. Further analyses should address on noninferiority analysis of aspirin compared with alternative anticoagulants and cost-effectiveness.