Zhu Z, Liang Y, Yan B, et al. - Researchers conducted this prospective study to assess the impact of conbercept with 3+ pro re nata (PRN) on macular perfusion status in patients with diabetic macular edema (DME) and quantitatively evaluate changes in foveal avascular zone (FAZ) areas and capillary density in macular regions by applying optical coherence tomography angiography (OCTA). According to the presence of ischemia on OCTA at baseline, 50 patients were divided into ischemic (n = 31) and non-ischemic (n = 19) groups. Intravitreal injections of 0.5 mg conbercept with 3+ PRN principle were obtained by all patients. Anti–vascular endothelial growth factor treatment can have a positive impact on macular perfusion status. In addition, in the macular perfusion status analysis, OCTA had advantages in quantifying and calculating blood flow index.