Cai C, Qiu G, Hong W, et al. - Whether continuous renal replacement therapy (CRRT) affords an efficacious as well as safe option for treating neonatal sepsis-related acute kidney injury (AKI), was investigated in this study by retrospectively analyzing data on 12 sepsis-related AKI neonates managed with CRRT in the neonatal intensive care unit of Shanghai Children’s Hospital between November 2012 and November 2019. Among participants, normal level (40–60 mmHg) of blood pressure (BP) could be achieved 12 h post- CRRT initiation, and the normal BP level could be maintained during the CRRT treatment. Following 12 h CRRT, the blood pH value rose to the normal range (7.35 ~ 7.45). A significant decline in serum potassium, serum urea nitrogen and serum creatinine levels was noted 12 h following CRRT initiation, and the normal range was achieved 24 h post-CRRT start. Overall, findings revealed that CRRT was safe as well as effective in the treatment of neonatal sepsis-related AKI.