Butler J, et al. - Researchers analyzed data from the National Cardiovascular Data Registry PINNACLE in order to determine the incidence, clinical features, treatment, and outcomes of patients with heart failure and reduced ejection fraction (HFrEF) who developed worsening heart failure (HF) in the real-world setting. They linked the data to pharmacy, private practitioner, and hospital claims databases. In African American individuals, octogenarians, and those with higher comorbidity burden, there was evidence of a greater likelihood of developing worsening HF. Development of worsening HF was reported in one in six patients with HFrEF; this was noted within 18 months of HF diagnosis in the real-world setting. A high risk for 2-year mortality and recurrent HF hospitalizations were observed in these patients. Low use of standard-of-care therapies was reported—both prior to and following the onset of worsening HF. A high unmet medical need was evident.