Haring R, Xanthakis V, Coviello A, et al. - Among older men included in the original cohort of the Framingham Heart Study, researchers investigated the short- (2-years; 1,165 person-observations in 528 people) as well as long-term (up to 10-years follow-up; 2520 person-observations in 835 people with mean baseline age: 71.2 years) clinical correlates of sex steroids and gonadotropins [total testosterone (TT), dehydroepiandrosterone sulphate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH) and total estradiol], employing multilevel modelling and Generalized Estimating Equations. They found an inverse link of age, body mass index and pre-existing type 2 diabetes, with long-term TT levels, whereas a positive link was displayed by higher systolic blood pressure. They also observed inverse link of age and pre-existing cardiovascular disease (CVD) with long-term DHEAS levels, and positive link of HDL cholesterol levels with long-term DHEAS levels. An inverse link of age with DHEAS but a positive association with FSH and LH levels were also revealed in analyses of short-term changes. Correlates of decreasing TT and DHEAS levels in elderly men were identified, which were modifiable. This implies that the age-associated fall of these hormones over late adulthood may be alleviated by maintaining a low CVD risk factor burden.