Righi D, Porco L, Calvieri C, et al. - This single-center case series was conducted to determine the characteristics, outcome as well as risk factors linked with cardiovascular and arrhythmic events among children < 12 years experiencing Brugada syndrome (BrS). This study involved 43 patients < 12 years-of-age at diagnosis. A median follow-up of 3.97 years was conducted. Findings revealed that a spontaneous type 1 Brugada ECG pattern was not related to a higher incidence of syncope, first-degree atrioventricular block, premature beats, non-malignant and malignant arrhythmic events (AEs), in comparison with drug/fever-induced type 1 Brugada ECG pattern. A correlation of syncope events with an elevated incidence of malignant AEs, was identified. A higher occurrence of malignant AEs was observed in relation to SCN5A mutations.