Lei Y, Feng H, Qiang H, et al. - The most malignant lung cancer, small cell lung cancer (SCLC), is sometimes mixed with non-small cell lung cancer (NSCLC, Non SCLC), then called combined small cell lung cancer (C-SCLC), so researchers sought to describe the clinical and pathologic features of C-SCLC. They enrolled 181 patients with stage Ⅰ-Ⅲa C-SCLC who had radical R0 surgery between 2009–2018 in Shanghai Chest Hospital. Most were small cell combined with large cell neuroendocrine components (SCLC/LCNEC: 58.0 %, N = 105), followed by adenocarcinoma (SCLC/ADC: 13.8 %, N = 25), and then squamous cell carcinoma (SCLC/SCC: 13.3%, N = 24). The most common type of C-SCLC was SCLC/LCNEC, and patients with SCLC/LCNEC had both longer DFS and OS vs other combination types. The main treatment for surgical C-SCLC is still adjuvant chemotherapy for SCLC.