Bernards SS, et al. - An inquiry was set up with regard to the correlation between BRCA1 and RAD51C promoter hypermethylation with similar survival and clinical characteristics. It was observed that patients with BRCA1-methylated carcinomas shared clinical characteristics with patients with BRCA1-mutated carcinomas including younger age and predominantly high grade serous (HGS) histology. Nevertheless, unlike mutation, RAD51C and BRCA1 methylation did not exhibit any connection with improved survival or greater sensitivity to platinum chemotherapy.