Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records
The Lancet Feb 21, 2020
Chen H, et al. - A retrospective review was conducted to assess the clinical characteristics of coronavirus disease (COVID-19) in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Researchers retrospectively examined clinical records, laboratory results, and chest CT scans for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. They further evaluated evidence of intrauterine vertical transmission by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. After the first lactation, breastmilk samples were also obtained and examined from individuals. It was indicated that clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult individuals who developed COVID-19 pneumonia. In women who develop COVID-19 pneumonia in late pregnancy, findings from this small group of cases imply that there is currently no data for intrauterine infection caused by vertical transmission.
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