Benatti B, Celebre L, Girone N, et al. - Researchers analyzed a large clinical sample of Italian obsessive-compulsive disorder (OCD) patients in order to determine gender disparities, given that OCD represents a heterogeneous disorder and gender may be a relevant factor in mediating this heterogeneity. They assessed 229 consecutive OCD outpatients through structured interviews. A greater likelihood of having lifetime psychiatric comorbidities was observed in female OCD patients vs male patients, with poly-comorbidities being twice as high vs males. Significant later onset of symptoms as well as a higher age at first treatment was noted in female patients. Higher rates of cleaning and washing compulsions were reported in the female subgroup vs male subgroup. Overall, the notion that OCD often exists as a comorbidity with other specific clinical features in female vs male patients was supported by the findings of this study. Consideration should be given to these data in epidemiologic as well as therapeutic perspectives.