Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Journal of Neurology, Neurosurgery & Psychiatry Nov 13, 2019
Tholance Y, Moritz CP, Rosier C, et al. - Given that antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly recognise a subgroup of sensory neuropathies (SNs) affecting mostly the dorsal root ganglion (DRG), researchers identified the frequency of anti-FGFR3 antibodies and the related clinical pattern in a large cohort of SN patients. Participants in the study were adults with pure SN. According to this prospective, multicentric, European and Brazilian study, 65 of 426 patients had anti-FGFR3 antibodies, the only autoimmune markers that were found in 43 patients. Investigators found that Brazilians had a higher anti-FGFR3 rate than Europeans and a more frequent asymmetric symptom distribution. Anti-FGFR3 antibodies are likely to occur in an SN subgroup that mainly affects the DRG. Differences between Europeans and Brazilians that indicate that genetic or environmental factors are involved.
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