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Clinical benefits of sex steroids given as a priming prior to GH provocative test or as a growth‐promoting therapy in peripubertal growth delays: Results of a retrospective study among ENDO‐ERN centres

Clinical Endocrinology Oct 19, 2020

Galazzi E, Improda N, Cerbone M, et al. - Researchers conducted this retrospective study to compare auxological outcomes of constitutional delay of growth and puberty (CDGP) or growth hormone deficiency (GHD) children undergoing primed or unprimed GH stimulation tests (GHST) and to evaluate low‐dose sex steroids (LDSS) treatment in CDGP. This investigation was carried out in three paediatric University Hospitals in Italy and the UK. One hundred eighty-four children (72 females) aged 12.4 ± 2.08 years underwent primed (/P+) or unprimed (/P−) GHST and were followed up until final height (FH). Priming before GHST improves the diagnostic precision of GHST for idiopathic GHD in peripubertal children. Treatment with LDSS improves auxological outcomes in CDGP.

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